He established the Liver Transplantation Programme at King Fahad National Guard Hospital in Riyadh in 1993, known as the first programme in the Middle East. He also established the Hepatobiliary Unit at King Saud University and King Khalid University Hospital in Riyadh, reactivated and established the Liver Transplant Program at KFSH & RC Riyadh in March 2021 and started the Living Donor Liver Transplant Program at KFSH & RC Riyadh in November 2022. Prof. Al Sebayel was the former Chairman of the Department of Liver & Small Bowel Transplantation & Hepatobiliary-Pancreatic Surgery and Director of the Liver Transplantation Programme at King Faisal Specialist Hospital & Research Centre (KFSH&RC). He was also Head of the Department of Hepatobiliary Surgery at King Khalid University Hospital and College of Medicine Riyadh and Chairman of the Department of Hepatobiliary Sciences at King Fahad National Guard Hospital Riyadh. He founded the National Donor Promotion Programme in the Kingdom of Saudi Arabia and the Pan Arab Liver Transplant Society in 2006.